Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …

Retinal ganglion cells (RGCs) convey the major output of information collected from the eye
to the brain. Thirty subtypes of RGCs have been identified to date. Here, we analyze 6225 …

Neurons in the central nervous system (CNS) lose their ability to regenerate early in
development, but the underlying mechanisms are unknown. By screening genes …

Phenotypic analysis of hematopoietic stem and progenitor cells (HSCs) has been an
invaluable tool in defining the biology of stem cell populations. We have recently described …

The optic nerve has been widely used to investigate factors that regulate axon regeneration
in the mammalian CNS. Although retinal ganglion cells (RGCs), the projection neurons of …

Postinjury recovery in most tissues requires an effective dialog with macrophages; however,
in the mammalian central nervous system, this dialog may be restricted (possibly due to its …

The central nervous system (CNS) loses the ability to regenerate early during development,
but it is not known why. The retina has long served as a simple model system for study of …

Enabling axon regeneration after central nervous system (CNS) injury remains a major
challenge in neurobiology. One of the major differences between the injured peripheral …

Inability to culture adult central neurons and the failure of injured neurons to regenerate in
the brain could be due to genetic controls or environmental inhibitors. We tested the …