Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Alzheimer's Disease (AD) is a challenging neurodegenerative condition, with overwhelming
implications for affected individuals and healthcare systems worldwide. Animal models have …

Aluminium is a non-essential metal and potentially toxic to organisms whose environmental
concentration increases due to pollution. In our previous studies, the behavioral changes …

Recent studies have shown guanylurea (GUA) alters the growth and development of fish,
induces oxidative stress, and disrupts the levels and expression of several genes …

Zebrafish are widely considered an excellent vertebrate model for studying the
pathogenesis of human diseases because of their transparency of embryonic development …

The key role of APP for Alzheimer pathogenesis is well established. However, perinatal
lethality of germline knockout mice lacking the entire APP family has so far precluded the …

Rodents have been the dominant animal models in neurobiology and neurological disease
research over the past 60 years. The prevalent use of rats and mice in neuroscience …

The prevalence of neurodegenerative diseases is increasing globally, with an imperative
need to identify and expand the availability of pharmaceutical treatment strategies …

Amyloid precursor protein (APP) has been widely studied due to its association with
Alzheimer's disease (AD). However, the physiological functions of APP are still largely …