Chloroplast genomes: diversity, evolution, and applications in genetic engineering

H Daniell, CS Lin, M Yu, WJ Chang - Genome biology, 2016 - Springer
Chloroplasts play a crucial role in sustaining life on earth. The availability of over 800
sequenced chloroplast genomes from a variety of land plants has enhanced our …

Therapeutic recombinant protein production in plants: Challenges and opportunities

MJB Burnett, AC Burnett - Plants, People, Planet, 2020 - Wiley Online Library
Societal Impact Statement Therapeutic protein production in plants is an area of great
potential for increasing and improving the production of proteins for the treatment or …

Targeted knockout of a conserved plant mitochondrial gene by genome editing

J Forner, D Kleinschmidt, EH Meyer, J Gremmels… - Nature Plants, 2023 - nature.com
Fusion proteins derived from transcription activator-like effectors (TALEs) have emerged as
genome editing tools for mitochondria. TALE nucleases (TALENs) have been applied to …

The production of recombinant pharmaceutical proteins in plants

JKC Ma, PMW Drake, P Christou - Nature reviews genetics, 2003 - nature.com
Imagine a world in which any protein, either naturally occurring or designed by man, could
be produced safely, inexpensively and in almost unlimited quantities using only simple …

Engineering plastid genomes: methods, tools, and applications in basic research and biotechnology

R Bock - Annual Review of Plant Biology, 2015 - annualreviews.org
The small bacterial-type genome of the plastid (chloroplast) can be engineered by genetic
transformation, generating cells and plants with transgenic plastid genomes, also referred to …

Molecular farming in plants: host systems and expression technology

RM Twyman, E Stoger, S Schillberg, P Christou… - TRENDS in …, 2003 - cell.com
Plants provide an inexpensive and convenient system for the large-scale production of
valuable recombinant proteins. This principle has been demonstrated by the commercial …

Plant-based production of biopharmaceuticals

R Fischer, E Stoger, S Schillberg, P Christou… - Current opinion in plant …, 2004 - Elsevier
Plants are now gaining widespread acceptance as a general platform for the large-scale
production of recombinant proteins. The first plant-derived recombinant pharmaceutical …

Plant‐made vaccines for humans and animals

EP Rybicki - Plant biotechnology journal, 2010 - Wiley Online Library
The concept of using plants to produce high‐value pharmaceuticals such as vaccines is 20
years old this year and is only now on the brink of realisation as an established technology …

Micro-algae come of age as a platform for recombinant protein production

E Specht, S Miyake-Stoner, S Mayfield - Biotechnology letters, 2010 - Springer
A complete set of genetic tools is still being developed for the micro-alga Chlamydomonas
reinhardtii. Yet even with this incomplete set, this photosynthetic single-celled plant has …

Plastid transformation in higher plants

P Maliga - Annu. Rev. Plant Biol., 2004 - annualreviews.org
▪ Abstract Plastids of higher plants are semi-autonomous organelles with a small, highly
polyploid genome and their own transcription-translation machinery. This review provides …