Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer

M Alam, S Alam, A Shamsi, M Adnan… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …

Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Tailoring the multi-functional properties of phospholipids for simple to complex self-assemblies

T Waghule, RN Saha, A Alexander, G Singhvi - Journal of Controlled …, 2022 - Elsevier
The unique interfacial properties, huge diversity, and biocompatible nature of phospholipids
make them an attractive pharmaceutical excipient. The amphiphilic nature of these …

Lipid-based nanovesicular drug delivery systems

T Limongi, F Susa, M Marini, M Allione, B Torre… - Nanomaterials, 2021 - mdpi.com
In designing a new drug, considering the preferred route of administration, various
requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a …

Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence

A Memarzia, S Saadat, F Asgharzadeh… - Journal of Cellular …, 2023 - Wiley Online Library
The most common type of cancer in the world is lung cancer. Traditional treatments have an
important role in cancer therapy. In the present review, the most recent findings on the …

Liposomes and phytosomes: nanocarrier systems and their applications for the delivery of phytoconstituents

Y Dutt, RP Pandey, M Dutt, A Gupta, A Vibhuti… - Coordination Chemistry …, 2023 - Elsevier
Phytochemicals, such as terpenes, polyphenols, and tannins, have been used in history, for
the treatment of illnesses and fever. Phytochemicals are easily available in nature, can be …

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

SS Gaikwad, YY Morade, AM Kothule, SJ Kshirsagar… - Heliyon, 2023 - cell.com
One of the major causes of death on the globe is cancer. It has remained a significant
obstacle for current therapies and has not yet been effectively treated. Conventional …

Carvacrol-loaded phytosomes for enhanced wound healing: Molecular docking, formulation, doe-aided optimization, and in vitro/in vivo evaluation

AM Tafish, M El-Sherbiny… - International Journal …, 2023 - Taylor & Francis
Background Despite recent advances in wound healing products, phytochemicals have
been considered promising and attractive alternatives. Carvacrol (CAR), a natural phenolic …

Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles

MW Al-Rabia, NA Alhakamy, WY Rizg, AF Alghaith… - Drug Delivery, 2022 - Taylor & Francis
Prostate cancer (PC) is emerging as one of the leading causes of mortality and morbidity
worldwide. Curcumin (CUR) is a well-known phytochemical, and scorpion venom (SV) is a …