Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Heavy metals and metalloid exposure are among the most common factors responsible for
reproductive toxicity in human beings. Several studies have indicated that numerous metals …

STUDY QUESTION Is it possible to co-culture and functionally link human liver and testis
equivalents in the combined medium circuit of a multi-organ chip? SUMMARY ANSWER …

Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and
in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that …

Infertility is a major global health issue and male factors account for half of all infertility
cases. One of the causes of male infertility is the loss of spermatogonial stem cells, which …

Autophagy is a major regulatory cellular mechanism which gives the cell an ability to cope
with some of the destructive events that normally occur within a metabolically living cell. This …

Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug.
This study aimed to address the toxic effects of CP on male fertility and the possible …

Objectives Reproductive malfunctions after chemotherapy still are a reason of reducing
fertility and need specialized intensive care. The aim of this review was to investigate the …

Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

The aim of the present study was to evaluate the protective effect of gallic acid (GA) against
cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was …