Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

The lysis-lysogeny decision of bacteriophage lambda (λ) is a paradigm for developmental
genetic networks. There are three key features, which characterize the network. First, after …

The HIV‐1 trans‐activator protein, tat, is an RNA binding protein with a high affinity for a U‐
rich bulge near the tip of the stem in the RNA stem‐loop structure encoded by the trans …

Termination signals induce rapid and irreversible dissociation of the nascent transcript from
RNA polymerase. Terminators at the end of genes prevent unintended transcription into the …

Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes.
For example, some cells lyse whereas others survive as lysogens. A quantitative biophysical …

The human immunodeficiency virus (HIV-1)-encoded trans-activator (tat) increases HIV
gene expression and replication. Previously, we demonstrated that tat facilitates elongation …

The vectorial (5′-to-3′ at varying velocity) synthesis of RNA by cellular RNA polymerases
(RNAPs) creates a rugged kinetic landscape, demarcated by frequent, sometimes long …

The 21 kd NusG protein is essential for E. coli viability. Cells depleted for NusG were
defective for factordependent transcription termination. Rho-induced polarity in the gal …

We have dissected the protein and nucleic acid determinants that direct a group of
transcriptional antiterminators to their specific target operons. These antiterminators, the N …

Antiterminator proteins control gene expression by recognizing control signals near the
promoter and preventing transcriptional termination which would otherwise occur at sites …