Importance Imaging biomarkers in Parkinson disease (PD) are increasingly important for
monitoring progression in clinical trials and also have the potential to improve clinical care …

Parkinson's disease (PD) is a common, progressive, and currently incurable
neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in …

Objective Randomized clinical trials have shown that aerobic exercise attenuates motor
symptom progression in Parkinson's disease, but the underlying neural mechanisms are …

The current review summarizes the current knowledge on longitudinal cortical and
subcortical grey and white matter MRI findings assessed using T1-weighted and one-tensor …

Parkinson's disease (PD) is the most common neurological disorder, after Alzheimer's
disease, and is characterized by a long prodromal stage lasting up to 20 years. As age is a …

Patients with loss of dopamine due to Parkinson's disease are impaired at learning from
reward. However, it remains unknown precisely which aspect of learning is impaired. In …

Cerebral small vessel disease is a common condition associated with lacunar stroke,
cognitive impairment and significant functional morbidity. White matter hyperintensities and …

Purpose: The identification of early-stage Parkinson's disease (PD) is important for the
effective management of patients, affecting their treatment and prognosis. Recently …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by both
motor and non‐motor symptoms. A convergent pathophysiological hallmark of PD is an early …

The recent validation of the α-synuclein seed amplification assay as a biomarker with high
sensitivity and specificity for the diagnosis of Parkinson's disease has formed the backbone …