Thermoresponsive interfaces obtained using poly (N-isopropylacrylamide)-based copolymer for bioseparation and tissue engineering applications

K Nagase - Advances in Colloid and Interface Science, 2021 - Elsevier
Abstract Poly (N-isopropylacrylamide)(PNIPAAm) is the most well-known and widely used
stimuli-responsive polymer in the biomedical field owing to its ability to undergo temperature …

Creation of softmaterials based on self-oscillating polymer gels

R Yoshida - Polymer Journal, 2022 - nature.com
In 1996, the author reported “self-oscillating” polymer gels that spontaneously repeat
swelling–deswelling changes in a closed solution without any on–off switching by external …

The increasing dynamic, functional complexity of bio-interface materials

BS Gomes, B Simões, PM Mendes - Nature Reviews Chemistry, 2018 - nature.com
In nature, interfacial molecular interactions are at the heart of all biological processes and
are mediated by diverse stimuli. Inspired by nature's responsive mechanisms and our …

Thermoresponsive block copolymer brush for temperature-modulated hepatocyte separation

K Nagase, N Kojima, M Goto, T Akaike… - Journal of Materials …, 2022 - pubs.rsc.org
Hepatic tissue engineering may be an effective approach for the treatment of liver disease;
however, its practical application requires hepatic cell separation technologies that do not …

[HTML][HTML] Thermoresponsive bio-affinity interfaces for temperature-modulated selective capture and release of targeted exosomes

K Nagase, K Yamazaki, Y Maekawa, H Kanazawa - Materials Today Bio, 2023 - Elsevier
The existing methods for exosome isolation, such as ultracentrifugation, size exclusion, and
affinity separation, suffer from some limitations. Herein, we aimed to develop temperature …

Temperature-modulated antibody drug separation using thermoresponsive mixed polymer brush-modified stationary phase

K Nagase, S Ishii, A Takeuchi, H Kanazawa - Separation and Purification …, 2022 - Elsevier
Recently, antibody drugs have been investigated for medical treatments of intractable
diseases. An effective antibody drug separation method is in demand for production of such …

Poly (N-isopropylacrylamide) based thermoresponsive polymer brushes for bioseparation, cellular tissue fabrication, and nano actuators

K Nagase, T Okano, H Kanazawa - Nano-Structures & Nano-Objects, 2018 - Elsevier
Many thermoresponsive surfaces for biomedical applications have been developed using
various techniques for modifying substrates with thermoresponsive polymers. In addition …

A thermoresponsive cationic block copolymer brush-grafted silica bead interface for temperature-modulated separation of adipose-derived stem cells

K Nagase, A Okada, J Matsuda, D Ichikawa… - Colloids and Surfaces B …, 2022 - Elsevier
Adipose-derived mesenchymal stem cells (ADSCs) have beneficial effects in cell
transplantation therapy; these cells are collected from adipose tissue using low-invasive …

Hydration and dehydration behaviors of poly (N-isopropylacrylamide)-grafted silica beads

K Nagase, J Matsuda, A Takeuchi, Y Ikemoto - Surfaces and Interfaces, 2023 - Elsevier
The use of poly (N-isopropyl acrylamide)(PNIPAAm) in thermoresponsive interfaces for
biomedical applications has been extensively investigated. Understanding the hydration …

Viral vector purification with thermoresponsive-anionic mixed polymer brush modified beads-packed column

K Nagase, S Kitazawa, T Kogure, S Yamada… - Separation and …, 2022 - Elsevier
Viral vectors have attracted attention as a potential new therapeutic modality for gene
therapy. In this study, we developed a temperature-modulated viral vector purification …