An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Background In the western world, 10–15% of women of child-bearing age suffer from iron-
deficiency anemia. Iron overload due to chronic treatment with blood transfusions or …

Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic
iron homeostasis through its interaction with ferroportin, the major cellular iron export …

The discovery of hepcidin has provided a solid foundation for understanding the
mechanisms of systemic iron homeostasis and the aetiologies of iron disorders. Hepcidin …

Iron, an essential trace element, plays a complex role in tumour biology. While iron causes
cancer clearance through toxic free radical generation, iron‐induced free radical flux also …

Osteoporosis is not well treated due to the difficulty of finding commonalities between the
various types of it. Iron homeostasis is a vital component in supporting biochemical …

The dysregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and/or solute carrier
family 7 member 11 (SLC7A11) is believed to contribute to ferroptosis in the hearts suffered …

Iron is an essential trace element for organisms. However, iron overload, which is common
in haematological disorders (eg haemochromatosis, myelodysplastic syndromes, aplastic …