The role of texture in the palatability and food oral processing

K Nishinari, MA Peyron, N Yang, Z Gao, K Zhang… - Food …, 2024 - Elsevier
Palatable food consumption brings us happiness and offers a longer-lasting sense of
pleasure compared to other forms of enjoyment, even as we age older (Brillat-Savarin …

Actions and Consequences of Insulin in the Striatum

JC Patel, KD Carr, ME Rice - Biomolecules, 2023 - mdpi.com
Insulin crosses the blood–brain barrier to enter the brain from the periphery. In the brain,
insulin has well-established actions in the hypothalamus, as well as at the level of …

A computational analysis of mouse behavior in the sucrose preference test

JPH Verharen, JW de Jong, Y Zhu, S Lammel - Nature communications, 2023 - nature.com
The sucrose preference test (SPT) measures the relative preference of sucrose over water to
assess hedonic behaviors in rodents. Yet, it remains uncertain to what extent the SPT …

Negative feedback control of hypothalamic feeding circuits by the taste of food

TJ Aitken, Z Liu, T Ly, S Shehata, N Sivakumar… - Neuron, 2024 - cell.com
The rewarding taste of food is critical for motivating animals to eat, but whether taste has a
parallel function in promoting meal termination is not well understood. Here, we show that …

[HTML][HTML] Ingested non-essential amino acids recruit brain orexin cells to suppress eating in mice

P Viskaitis, M Arnold, C Garau, LT Jensen, L Fugger… - Current Biology, 2022 - cell.com
Ingested nutrients are proposed to control mammalian behavior by modulating the activity of
hypothalamic orexin/hypocretin neurons (HONs). Previous in vitro studies showed that …

Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice

CT Wu, DG Magaña, J Roshgadol, L Tian, KK Ryan - Appetite, 2024 - Elsevier
A growing literature suggests manipulating dietary protein status decreases sweet
consumption in rodents and in humans. Underlying neurocircuit mechanisms have not yet …

[HTML][HTML] Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking

PA Starski, TDO Sergio, FW Hopf - Addiction neuroscience, 2023 - Elsevier
Alcohol use disorder extracts substantial personal, social and clinical costs, and continued
intake despite negative consequences (compulsion-like consumption) can contribute …

Behavioral tests of the insulin-cholinergic-dopamine link in nucleus accumbens and inhibition by high fat-high sugar diet in male and female rats

SP Weiner, KD Carr - Physiology & Behavior, 2024 - Elsevier
It was previously shown in striatal slices obtained from male rats that insulin excites
cholinergic interneurons and increases dopamine (DA) release via α4β2 nicotinic receptors …

Dietary protein restriction modulates 'dessert'intake after a meal, via fibroblast growth factor 21 (FGF21)

CT Wu, KR Larson, LC Sims, KK Ryan - Physiology & Behavior, 2023 - Elsevier
Pharmacological administration of fibroblast growth factor 21 (FGF21) alters food choice,
including that it decreases the consumption of sucrose and other sweet tastants. Conversely …

An operant ethanol self-administration paradigm that discriminates between appetitive and consummatory behaviors reveals distinct behavioral phenotypes in …

R Patwell, H Yang, SC Pandey, EJ Glover - Neuropharmacology, 2021 - Elsevier
Alcohol use disorder (AUD) constitutes a major burden to global health. Recently, the
translational success of animal models of AUD has come under increased scrutiny. Efforts to …