MDSCs might be “Achilles heel” for eradicating CSCs

T Yang, N Liang, J Li, P Hu, Q Huang, Z Zhao… - Cytokine & Growth …, 2022 - Elsevier
During tumor initiation and progression, the complicated role of immune cells in the tumor
immune microenvironment remains a concern. Myeloid-derived suppressor cells (MDSCs) …

Therapeutic targeting of cancer stem cells in lung, head and neck, and bladder cancers

SE Mudra, P Sadhukhan, MT Ugurlu, S Alam… - Cancers, 2021 - mdpi.com
Simple Summary Effective cancer treatment hinges upon overcoming therapeutic resistance
mechanisms that allow for the continued proliferation of cancer cell subpopulations …

Immunomodulatory functions of the circ_001678/miRNA-326/ZEB1 axis in non-small cell lung cancer via the regulation of PD-1/PD-L1 pathway

Q Tian, T Wu, X Zhang, K Xu, X Yin… - Human Molecular …, 2022 - academic.oup.com
High-throughput circular RNA (circRNA) sequencing identified circRNA_001678
(circ_001678) as an upregulated circRNA in non-small cell lung cancer (NSCLC) tissues …

Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of …

Z Zhou, X Wu, R Zhan, X Li, D Cheng… - Cancer Biology & …, 2022 - Taylor & Francis
Our previous studies have demonstrated that human papillomavirus (HPV)-16 E7
oncoprotein promoted epithelial-mesenchymal transition (EMT) in non-small cell lung …

A miRNA-based prognostic model to trace thyroid cancer recurrence

EA Toraih, MS Fawzy, B Ning, M Zerfaoui, Y Errami… - Cancers, 2022 - mdpi.com
Simple Summary Some thyroid tumors elected for surveillance remain indolent, while others
progress. The mechanism responsible for this difference is poorly understood, making it …

Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing

R Kaur, PK Suresh - Applied Biochemistry and Biotechnology, 2024 - Springer
Globally, lung cancer contributes significantly to the public health burden–associated
mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay …

Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia

SA Vlahopoulos, L Varisli… - International …, 2024 - spandidos-publications.com
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a member of the aldehyde
dehydrogenase gene subfamily that encode enzymes with the ability to oxidize …

LncRNA-SERB promotes vasculogenic mimicry (VM) formation and tumor metastasis in renal cell carcinoma

S Tang, F Chen, J Zhang, F Chang, Z Lv, K Li… - Journal of Biological …, 2024 - ASBMB
A growing body of evidence shows that vasculogenic mimicry (VM) is closely related to the
invasion and metastasis of many tumor cells. Although the estrogen receptor (ER) can …

Reciprocal relationship between cancer stem cells and myeloid-derived suppressor cells: implications for tumor progression and therapeutic strategies

G Ding, H Yu, J Jin, X Qiao, J Ma, T Zhang… - Future Oncology, 2024 - Taylor & Francis
Recently, there has been an increased focus on cancer stem cells (CSCs) due to their
resilience, making them difficult to eradicate. This resilience often leads to tumor recurrence …