Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Interest in the amyloid precursor protein (APP) has increased in recent years due to its
involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and …

Rodent models have been extensively used to investigate the cause and mechanisms
behind Alzheimer's disease. Despite many years of intensive research using these models …

The amyloid precursor protein (APP) is a type I transmembrane glycoprotein better known
for its participation in the physiopathology of Alzheimer disease as the source of the beta …

Alzheimer's disease (AD) is the most common neurodegenerative disease caused by
eventually aggregated amyloid β (Aβ) plaques in degenerating neurons of the aging brain …

Background Amyloid-β plaques are a defining characteristic of Alzheimer Disease.
However, Amyloid-β deposition is also found in other forms of dementia and in non …

Here, we present methods for the development of assays to query potentially clinically
significant nonsynonymous changes using in vivo complementation in zebrafish. Zebrafish …

The zebrafish (Danio rerio) is one of the most promising new model organisms. The
increasing popularity of this amazing small vertebrate is evident from the exponentially …

Neurological diseases, including neurodegenerative and neurodevelopmental disorders,
affect nearly one in six of the world's population. The burden of the resulting deaths and …

Highlights•Abeta peptide biology rather than APP biology has been the main focus of AD
field in the past 20 years.•The amyloid cascade hypothesis failed to produce effective AD …