Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …

Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …

Chemo-brain refers to the thinking and memory problems that occur in cancer patients
during and after chemotherapy. It is also known as cognitive dysfunction or chemo-fog. Risk …

5-Fluorouracil (5-FU) is a chemotherapeutic drug with a good anti-cancer effect on various
types of cancers, such as colorectal cancer and breast cancer. However, previous studies …

Cognitive dysfunction has been one of the most reported and studied adverse effects of
cancer treatment, but, for many years, it was overlooked by the medical community …

Traditional cancer therapies induce lasting alterations to multiple neural cell types. Therapy-
induced microglial activation is a critical component of the cause of CRCI, contributing to …

Cancer treatment is associated with long lasting cognitive impairment in cancer survivors.
This cognitive impairment is often termed cancer related cognitive impairment (CRCI) …

Cancer is the second leading cause of death worldwide despite efforts in early diagnosis of
the disease and advances in treatment. The use of drugs that exert toxic effects on tumor …