Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by
autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests …

The Ashwell receptor, the major lectin of hepatocytes, rapidly clears from blood circulation
glycoproteins bearing glycan ligands that include galactose and N-acetylgalactosamine …

Although surface sialic acid is considered a key determinant for the survival of circulating
blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We …

Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD)
as well as stroke. Endothelial metabolic disorder has been found to be activated and then …

Among known platelet proteins, a prominent and functionally important group is represented
by glycoprotein isoforms. They account eg for secretory proteins and plasma membrane …

Presentation of sialic acid (Sia) varies among different tissues and organs within each
species, and between species. This diversity has biologically important consequences …

Background: Cardiac sialylation is involved in a variety of physiological processes in the
heart. Altered sialylation has been implicated in heart failure (HF) mice. However, its role in …

Platelets respond to vascular damage and contribute to inflammation, but their role in the
neurodegenerative diseases is unknown. We found that the systemic administration of brain …

Platelets play a pivotal role in physiological hemostasis. However, in coronary arteries
damaged by atherosclerosis, enhanced platelet aggregation, with subsequent thrombus …

There is increasing interest in developing novel coatings to enhance the biocompatibility of
medical implants. A key issue in biocompatibility research is platelet activation and …