Fibroblast growth factor signalling in the diseased nervous system

L Klimaschewski, P Claus - Molecular Neurobiology, 2021 - Springer
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …

Targeting R ho‐GTP ases in immune cell migration and inflammation

M Biro, MA Munoz, W Weninger - British journal of …, 2014 - Wiley Online Library
Leukocytes are unmatched migrators capable of traversing barriers and tissues of
remarkably varied structural composition. An effective immune response relies on the ability …

A genome-wide association study of anorexia nervosa

V Boraska, CS Franklin, JAB Floyd, LM Thornton… - Molecular …, 2014 - nature.com
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

Small molecule targeting Cdc42–intersectin interaction disrupts Golgi organization and suppresses cell motility

A Friesland, Y Zhao, YH Chen… - Proceedings of the …, 2013 - National Acad Sciences
Signaling through the Rho family of small GTPases has been intensely investigated for its
crucial roles in a wide variety of human diseases. Although RhoA and Rac1 signaling …

Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder

Z Zhao, J Xu, J Chen, S Kim, M Reimers… - Molecular …, 2015 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high
heritability. Clinicians have long noticed the similarities of clinic symptoms between these …

Graphene-regulated cardiomyogenic differentiation process of mesenchymal stem cells by enhancing the expression of extracellular matrix proteins and cell signaling …

J Park, S Park, S Ryu, SH Bhang, J Kim… - Advanced healthcare …, 2013 - europepmc.org
The potential of graphene as a mesenchymal stem cell (MSC) culture substrate to promote
cardiomyogenic differentiation is demonstrated. Graphene exhibits no sign of cytotoxicity for …

Pharmacological modulators of small GTPases of rho family in neurodegenerative diseases

W Guiler, A Koehler, C Boykin, Q Lu - Frontiers in Cellular …, 2021 - frontiersin.org
Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small
GTPase superfamily and play essential roles in a variety of cellular functions. Rho GTPase …

Neurotrophin signaling and stem cells—implications for neurodegenerative diseases and stem cell therapy

S Pramanik, YA Sulistio, K Heese - Molecular neurobiology, 2017 - Springer
Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …

FilGAP and its close relatives: a mediator of Rho–Rac antagonism that regulates cell morphology and migration

F Nakamura - Biochemical Journal, 2013 - portlandpress.com
Cell migration, phagocytosis and cytokinesis are mechanically intensive cellular processes
that are mediated by the dynamic assembly and contractility of the actin cytoskeleton. GAPs …

Autophagy negatively regulates early axon growth in cortical neurons

BK Ban, MH Jun, HH Ryu, DJ Jang… - … and cellular biology, 2013 - Am Soc Microbiol
Neurite growth requires neurite extension and retraction, which are associated with protein
degradation. Autophagy is a conserved bulk degradation pathway that regulates several …