The oral route is the most widely used and preferable way of drug administration. Several
pharmacokinetic processes play a role in the distribution of administered drugs. Therefore …

Nuclear imaging plays a unique role within diagnostic imaging since it focuses on cellular
and molecular processes. Using different radiotracers and detection techniques such as the …

Purpose: Efforts have been devoted to select eligible candidates for PD-1/PD-L1 immune
checkpoint blocker (ICB) immunotherapy. Here, we have a serendipitous finding of positron …

Kirsten rat sarcoma (KRAS) mutations are an important marker for tumor-targeted therapy. In
this study, we sought to develop a KRASG12C oncoprotein–targeted PET tracer and to …

BACKGROUND Considering that trophoblast cell-surface antigen 2 (Trop2) is
overexpressed in a wide range of human epithelial cancers, it presents an attractive target …

Abstract Background In the US, EU and elsewhere, basic clinical research studies with
positron emission tomography (PET) radiotracers that are generally recognized as safe and …

In nuclear medicine, estimating the number of radioactive decays that occur in a source
organ per unit administered activity of a radiopharmaceutical (ie, the time-integrated activity …

Background [18 F] F-FDG,[68 Ga] Ga-PSMA-11, and [68 Ga] Ga-FAPI-04 have achieved
good results in multiple clinical trials and clinical practice, but the imaging of these tracers is …

Objective and background The objective of this first-in-human study was to investigate the
radiosynthesis, and the preliminary safety, biodistribution, and organ radiation dosimetry of …

Purpose Treatment of pediatric cancers with doxorubicin is a common and predictable
cause of cardiomyopathy. Early diagnosis of treatment-induced cardiotoxicity and …