Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Neurofibromatosis type 1 (NF1), also called von Recklinghausen disease or peripheral
neurofibromatosis, is a common autosomal dominant disorder characterised by multiple …

Abstract Neurofibromatosis type 1 (NF1) is a relatively common tumour predisposition
syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene …

Von Recklinghausen neurofibromatosis, or type 1 neurofibromatosis (NF1), is a common
autosomal dominant disorder characterized by abnormalities in multiple tissues derived from …

Individuals with neurofibromatosis type 1 (NF1) have an increased risk of developing benign
and malignant tumours. The NF1 gene is thought to be a tumour suppressor gene, yet no …

Neurofibromin is a cytoplasmic protein that is predominantly expressed in neurons,
Schwann cells, oligodendrocytes, astrocytes and leukocytes. It is encoded by the gene NF1 …

Retroviruses induce myeloid leukaemia in BXH-2 mice by the insertional mutation of cellular
proto-oncogenes or tumour suppressor genes. Disease genes can thus be identified by …

Neurofibromatosis 1 maps to chromosome band 17q11. 2, and the NF1 locus has been
partially characterized. Even though the full-length NF1 cDNA has been sequenced, the …

Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas typically
developing in the context of neurofibromatosis type 1 (NF-1). With the exception of surgical …

Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized
by marked variation in clinical severity. To investigate the contribution to variability by genes …