Bone metastases are devastating complications of cancer. They are particularly common in
prostate cancer (PCa), represent incurable disease, and are refractory to immunotherapy …

Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected
patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of …

Abstract Background Circular RNAs (circRNAs) constitute a family of transcripts with unique
structures and have been confirmed to be critical in tumorigenesis and to be potential …

High-grade glioma is one of the most lethal human cancers characterized by extensive
tumor heterogeneity. In order to identify cellular and molecular mechanisms that drive tumor …

Metastasis is the principal cause of cancer related deaths. Tumor invasion is essential for
metastatic spread. However, determinants of invasion are poorly understood. We addressed …

Bats are reservoir hosts of many zoonotic viruses with pandemic potential. We utilized single-
cell transcriptome sequencing (scRNA-seq) to analyze the immune response in bat lungs …

Eutopic endometrium appears to be crucial for endometriosis development. Despite of the
evident importance, data regarding the cellular microenvironment remain unclear. Our …

Acute myeloid leukemia (AML) is a genetically extremely heterogeneous disease. Drug
resistance after induction therapy is a very frequent event resulting in poor medium survival …

Expression of the immediate-early response gene IER2 has been associated with the
progression of several types of cancer, but its functional role is poorly understood. We found …

Currently, the oncogenic mechanism of endoplasmic reticulum stress‐CAF (ERS‐CAF)
subpopulation in chordoma remains unknown. Here, single‐cell RNA sequencing, spatial …