Neural networks for navigation: From connections to computations

RI Wilson - Annual Review of Neuroscience, 2023 - annualreviews.org
Many animals can navigate toward a goal they cannot see based on an internal
representation of that goal in the brain's spatial maps. These maps are organized around …

Flexible navigational computations in the Drosophila central complex

YE Fisher - Current opinion in neurobiology, 2022 - Elsevier
Insects can perform impressive feats of navigation, suggesting a sophisticated sense of
direction and an ability to choose appropriate trajectories toward ethological goals. The …

Converting an allocentric goal into an egocentric steering signal

P Mussells Pires, L Zhang, V Parache, LF Abbott… - Nature, 2024 - nature.com
Neuronal signals that are relevant for spatial navigation have been described in many
species,,,,,,,,–. However, a circuit-level understanding of how such signals interact to guide …

Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster

N Eckstein, AS Bates, A Champion, M Du, Y Yin… - Cell, 2024 - cell.com
High-resolution electron microscopy of nervous systems has enabled the reconstruction of
synaptic connectomes. However, we do not know the synaptic sign for each connection (ie …

Drosophila olfaction: past, present and future

R Benton - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
Among the many wonders of nature, the sense of smell of the fly Drosophila melanogaster
might seem, at first glance, of esoteric interest. Nevertheless, for over a century, the 'nose'of …

Neural circuits for goal-directed navigation across species

J Basu, K Nagel - Trends in Neurosciences, 2024 - cell.com
Across species, navigation is crucial for finding both resources and shelter. In vertebrates,
the hippocampus supports memory-guided goal-directed navigation, whereas in arthropods …

[HTML][HTML] Driver lines for studying associative learning in Drosophila

Y Shuai, M Sammons, G Sterne, K Hibbard, H Yang… - eLife, 2024 - elifesciences.org
The mushroom body (MB) is the center for associative learning in insects. In Drosophila,
intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the …

Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila

AV Devineni, KM Scaplen - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses
based on changes in the environmental context, internal state, or experience. Studies in …

Transforming a head direction signal into a goal-oriented steering command

EA Westeinde, E Kellogg, PM Dawson, J Lu… - Nature, 2024 - nature.com
To navigate, we must continuously estimate the direction we are headed in, and we must
correct deviations from our goal. Direction estimation is accomplished by ring attractor …

New genetic tools for mushroom body output neurons in Drosophila

GM Rubin, Y Aso - Elife, 2024 - elifesciences.org
How memories of past events influence behavior is a key question in neuroscience. The
major associative learning center in Drosophila, the mushroom body (MB), communicates to …