Microdialysis (MD) was introduced as an intracerebral sampling method for clinical
neurosurgery by Hillered et al. and Meyerson et al. in 1990. Since then MD has been …

Background Microdialysis is used in many European neurointensive care units to monitor
brain chemistry in patients suffering subarachnoid hemorrhage (SAH) or traumatic brain …

Omega-3 fatty acids (ie, docosahexaenoic acid; DHA) regulate signal transduction and gene
expression, and protect neurons from death. In this study we examined the capacity of …

OBJECTIVE The study was undertaken to measure baseline values for chemical markers in
human subjects during wakefulness, anesthesia, and neurosurgery, using intracerebral …

Disturbed glucose brain metabolism after brain trauma is reflected by changes in
extracellular glucose levels. The authors hypothesized that posttraumatic reductions in …

OBJECTIVE Brain interstitial glycerol was studied as a potential marker for membrane
phospholipid degradation in acute human brain injury. METHODS Glycerol was measured …

Oxidative stress after traumatic brain injury may contribute to many of the pathophysiologic
changes. Resveratrol, naturally present at high concentration in grape skin, seeds, and red …

The pathology of traumatic brain injury (TBI) is characterized by the decreased capacity of
neurons to metabolize energy and sustain synaptic function, likely resulting in cognitive and …

OBJECTIVE Intracerebral microdialysis has been demonstrated to be a useful method for
detection of brain ischemia in experimental models and in patients. We have applied new …

BACKGROUND: Although various strategies for prevention of brain disease have been
implemented, no substance has been found to be advantageous for prophylaxis against …