Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

The prognosis of intracerebral haemorrhage continues to be devastating despite much
research into this condition. A prominent feature of intracerebral haemorrhage is …

Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with
surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the …

Despite enormous advances made in the development of external effector prosthetics over
the last quarter century, significant questions remain, especially those concerning signal …

Neutrophils are thought to contribute to damage after intracerebral hemorrhage (ICH), but
there is little direct evidence for this. We depleted circulating blood neutrophils with an anti …

The inflammatory response triggered by stroke has been viewed as harmful, focusing on the
influx and migration of blood-borne leukocytes, neutrophils, and macrophages. This review …

No effective therapy is available for treating intracerebral hemorrhage (ICH). One of several
key components of brain damage after ICH is the neurotoxicity of blood products. Within …

Peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor that regulates
the expression of various gene products that are essential in lipid and glucose metabolism …

Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the
hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular …