Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

This review addresses oxidative stress and redox signaling in the pancreas under
physiological conditions as well as in acute pancreatitis, chronic pancreatitis, pancreatic …

Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis,
triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1) …

Acute pancreatitis (AP) is a disease characterized by local and systemic inflammation with
an increasing incidence worldwide. Receptor-interacting serine/threonine protein kinase 3 …

In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly
decreased. This situation is associated with the absence in clinical practice of highly …

As a serine/threonine protein kinase, receptor-interacting protein 1 (RIP1) plays an important
role in regulating the pathways in programmed cell death. Multifaceted human diseases (eg …

The purpose of this study was to explore whether and how endoplasmic reticulum stress
(ERS) could promote caspase-1-dependent pancreatic acinar cell pyroptosis via the protein …

Acute pancreatitis (AP) is a common cause of a clinically acute abdomen. Crosstalk between
acinar cells and leukocytes (especially macrophages) plays an important role in the …

Within the field of medical science, there is a great deal of interest in investigating cell death
pathways in the hopes of discovering new drugs. Over the past two decades …

Acute pancreatitis (AP) is a frequent abdominal inflammatory disease. Despite the high
morbidity and mortality, the management of AP remains unsatisfactory. Disulfiram (DSF) is …