Gait impairments are among the most common and disabling symptoms of Parkinson's
disease. Nonetheless, gait is not routinely assessed quantitatively but is described in …

Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia)
have a long history and primarily model the consequences of dopamine loss in the basal …

Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …

Pathologically increased beta power has been described as a biomarker for Parkinson's
disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we …

Freezing of gait (FOG) is a devastating axial motor symptom in Parkinson's disease (PD)
leading to falls, institutionalization, and even death. The response of FOG to dopaminergic …

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for the
motor symptoms of Parkinson's disease (PD). However, the neural elements mediating …

Parkinson's disease (PD) is becoming a major public-health issue in an aging population.
Available approaches to treat advanced PD still have limitations; new therapies are needed …

Objective Applications of brain–computer interfacing (BCI) in neurorehabilitation have
received increasing attention. The intention to perform a motor task can be detected from …

Abstract Objectives Patients with Parkinson's disease (PD) have deficits in lower-limb
functions such as gait, which involves both cognitive and motor dysfunction. In PD, theta and …

Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based
neurostimulation, with the potential of clinical implementation with the sensing-enabled …