Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Complex fluids of poly (oxyethylene) monoalkyl ether nonionic surfactants

R Dong, J Hao - Chemical reviews, 2010 - ACS Publications
Complex Fluids of Poly(oxyethylene) Monoalkyl Ether Nonionic Surfactants | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …

Structural properties of pure simple alcohols from ethanol, propanol, butanol, pentanol, to hexanol: Comparing Monte Carlo simulations with experimental SAXS data

M Tomšič, A Jamnik, G Fritz-Popovski… - The Journal of …, 2007 - ACS Publications
The primary liquid alcohols from ethanol to 1-hexanol were studied utilizing the
configurational-bias Monte Carlo (MC) simulations of the modeled alcohols (transferable …

Novel microemulsion-based gels for topical delivery of indomethacin: Formulation, physicochemical properties and in vitro drug release studies

A Froelich, T Osmałek, A Snela, P Kunstman… - Journal of colloid and …, 2017 - Elsevier
Hypothesis Microemulsion-based semisolid systems may be considered as an interesting
alternative to the traditional dosage forms applied in topical drug delivery. Mechanical …

Modification of adsorption, aggregation and wetting properties of surfactants by short chain alcohols

A Zdziennicka, B Jańczuk - Advances in Colloid and Interface Science, 2020 - Elsevier
The adsorption of methanol, ethanol and propan-1-ol at the solution-air and solid-solution
interfaces, their aggregation in the aqueous media as well as wetting properties regarding …

Nanoemulsion: An advanced vehicle for efficient drug delivery

A Ali, VA Ansari, U Ahmad, J Akhtar, A Jahan - Drug research, 2017 - thieme-connect.com
Advanced drug delivery system has now gained preference over the conventional drug
delivery system. One such research is nanoemulsion which is famous among the …

Microemulsions as novel drug carriers: the formation, stability, applications and toxicity

HY Karasulu - Expert opinion on drug delivery, 2008 - Taylor & Francis
A microemulsion, made from water, oil, surfactants and cosurfactant is a thermodynamically
stable system. The presence of the cosurfactant is often required in order to lower the …

Microemulsions with an ionic liquid surfactant and room temperature ionic liquids as polar pseudo-phase

O Zech, S Thomaier, P Bauduin, T Rück… - The Journal of …, 2009 - ACS Publications
In this investigation we present for the first time microemulsions comprising an ionic liquid as
surfactant and a room-temperature ionic liquid as polar pseudo-phase. Microemulsions …

[图书][B] Ion Exchange and Solvent Extraction: A Series of Advances, Volume 19

BA Moyer - 2009 - taylorfrancis.com
The growth in the world's nuclear industry, motivated by peaking world oil supplies,
concerns about the greenhouse effect, and domestic needs for energy independence, has …

Understanding the Effect of the Phase Modifier n-Octanol on Extraction, Aggregation, and Third-Phase Appearance in Solvent Extraction

Z Lu, S Dourdain, S Pellet-Rostaing - Langmuir, 2020 - ACS Publications
Phase modifiers are often added to solvent extraction processes to avoid the third-phase
formation. While this important issue was attributed to sticky interactions between reverse …