The RNA polymerase II core promoter
ST Smale, JT Kadonaga - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …
The general transcription machinery and general cofactors
MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
Genome-wide analysis of mammalian promoter architecture and evolution
Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG …
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG …
Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage
T Shiraki, S Kondo, S Katayama… - Proceedings of the …, 2003 - National Acad Sciences
We introduce cap analysis gene expression (CAGE), which is based on preparation and
sequencing of concatamers of DNA tags deriving from the initial 20 nucleotides from 5′ end …
sequencing of concatamers of DNA tags deriving from the initial 20 nucleotides from 5′ end …
The RNA polymerase II core promoter: a key component in the regulation of gene expression
JEF Butler, JT Kadonaga - Genes & development, 2002 - genesdev.cshlp.org
The development, growth, and survival of eukaryotic organisms require the proper
regulation of tens of thousands of genes. By complex formulae that have yet to be solved …
regulation of tens of thousands of genes. By complex formulae that have yet to be solved …
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes
K Kimura, A Wakamatsu, Y Suzuki, T Ota… - Genome …, 2006 - genome.cshlp.org
By analyzing 1,780,295 5′-end sequences of human full-length cDNAs derived from 164
kinds of oligo-cap cDNA libraries, we identified 269,774 independent positions of …
kinds of oligo-cap cDNA libraries, we identified 269,774 independent positions of …
Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters
The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …
Computational analysis of core promoters in the Drosophila genome
Background The core promoter, a region of about 100 base-pairs flanking the transcription
start site (TSS), serves as the recognition site for the basal transcription apparatus …
start site (TSS), serves as the recognition site for the basal transcription apparatus …
NF-Y and the transcriptional activation of CCAAT promoters
D Dolfini, R Gatta, R Mantovani - Critical reviews in biochemistry …, 2012 - Taylor & Francis
The CCAAT box promoter element and NF-Y, the transcription factor (TF) that binds to it,
were among the first cis-elements and trans-acting factors identified; their interplay is …
were among the first cis-elements and trans-acting factors identified; their interplay is …
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
G Eades, Y Yao, M Yang, Y Zhang, S Chumsri… - Journal of Biological …, 2011 - ASBMB
Evidence supports a critical role for microRNAs (miRNAs) in regulation of tissue-specific
differentiation and development. Signifying a disruption of these programs, expression …
differentiation and development. Signifying a disruption of these programs, expression …