Depression in older adults

A Fiske, JL Wetherell, M Gatz - Annual review of clinical …, 2009 - annualreviews.org
Depression is less prevalent among older adults than among younger adults, but it can have
serious consequences. More than half of cases represent a first onset in later life. Although …

Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease

B Fonseca-Santos, MPD Gremião… - International Journal of …, 2015 - Taylor & Francis
Alzheimer's disease is a neurological disorder that results in cognitive and behavioral
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …

Neuropsychiatric symptoms in Alzheimer's disease

CG Lyketsos, MC Carrillo, JM Ryan… - Alzheimer's & …, 2011 - Elsevier
Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related
dementias. Once thought to emerge primarily in people with late-stage disease, these …

Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults

NJ Donovan, JJ Locascio, GA Marshall… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: To understand the role of depressive symptoms in preclinical Alzheimer's
disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in …

Depression in late life: review and commentary

DG Blazer - The journals of gerontology series A: Biological …, 2003 - academic.oup.com
Depression is perhaps the most frequent cause of emotional suffering in later life and
significantly decreases quality of life in older adults. In recent years, the literature on late-life …

Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study

CG Lyketsos, O Lopez, B Jones, AL Fitzpatrick… - Jama, 2002 - jamanetwork.com
ContextMild cognitive impairment (MCI) may be a precursor to dementia, at least in some
cases. Dementia and MCI are associated with neuropsychiatric symptoms in clinical …

Depression in the elderly

GS Alexopoulos - The lancet, 2005 - thelancet.com
In elderly people, depression mainly affects those with chronic medical illnesses and
cognitive impairment, causes suffering, family disruption, and disability, worsens the …

Late-life depression, mild cognitive impairment, and dementia: possible continuum?

F Panza, V Frisardi, C Capurso, A D'Introno… - The American Journal of …, 2010 - Elsevier
Clinical and epidemiologic research has focused on the identification of risk factors that may
be modified in predementia syndromes, at a preclinical and early clinical stage of dementing …

Neuropsychiatric symptoms in Alzheimer's disease: What might be associated brain circuits?

PB Rosenberg, MA Nowrangi, CG Lyketsos - Molecular aspects of medicine, 2015 - Elsevier
Neuropsychiatric symptoms (NPS) are very common in Alzheimer's disease (AD),
particularly agitation, apathy, depression, and delusions. Brain networks or circuits …

Mood disorders in the medically ill: scientific review and recommendations

DL Evans, DS Charney, L Lewis, RN Golden… - Biological …, 2005 - Elsevier
OBJECTIVE: The purpose of this review is to assess the relationship between mood
disorders and development, course, and associated morbidity and mortality of selected …