Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …

Gene expression is needed for the maintenance of heart function under normal conditions
and in response to stress. Each cell type of the heart has a specific program controlling …

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular
mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response …

Rationale: ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by
the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic …

Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …

Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs
in structurally normal heart and no transient or reversible arrhythmia factors, such as …

The temporal nature of chromatin structural changes underpinning pathologic transcription
are poorly understood. We measured chromatin accessibility and DNA methylation to study …

Rationale: Identifying genetic markers for heterogeneous complex diseases such as heart
failure is challenging and requires prohibitively large cohort sizes in genome-wide …

Epigenetics is a rapidly developing science that has gained a lot of interest in recent years
due to the correlation between characteristic epigenetic marks and cardiovascular diseases …