Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …

No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating
neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease …

The neuroprotective effect of the glial cell line-derived neurotrophic factor has been
extensively studied in various toxic models of Parkinson's disease. However, it remains …

Bidirectional molecular communication between the motoneuron and the muscle is vital for
neuromuscular junction (NMJ) formation and maintenance. The molecular mechanisms …

Giant axonal neuropathy (GAN) is an early-onset neurological disorder caused by mutations
in the GAN gene (encoding for gigaxonin), which is predicted to be an E3 ligase adaptor. In …

The glial cell line-derived neurotrophic factor (GDNF) was first identified as a survival factor
for midbrain dopaminergic neurons, but additional studies provided evidences for a role as a …

Glial cell line-derived neurotrophic factor (GDNF) and Neurturin (NRTN) bind to a receptor
complex consisting of a member of the GDNF family receptor (GFR)-α and the Ret tyrosine …

Neurotrophic factors and their receptors play a central role in neuronal survival. Since
neurons have a highly polarized morphology, target-derived neurotrophic factor signaling is …

RET encodes a receptor tyrosine kinase that is essential for spermatogenesis, development
of the sensory, sympathetic, parasympathetic, and enteric nervous systems and the kidneys …

Glial cell line-derived neurotrophic factor (GDNF) promotes PNS development and kidney
morphogenesis via a receptor complex consisting of the glycerophosphatidylinositol (GPI) …