Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of
multiple model organisms. Early research on neural crest cells (NCCs) was dominated by …

Sensory fibers of the peripheral nervous system carry sensation from specific sense
structures or use different tissues and organs as receptive fields, and convey this information …

Neural crest cells are crucial in development, not least because of their remarkable
multipotency. Early findings stimulated two hypotheses for how fate specification and …

Neural crest cells (NCCs) are vertebrate stem cells that give rise to various cell types
throughout the developing body in early life. Here, we utilized single-cell transcriptomic …

Mechanisms generating diverse cell types from multipotent progenitors are fundamental for
normal development. Pigment cells are derived from multipotent neural crest cells and their …

Understanding how fate specification of distinct cell-types from multipotent progenitors
occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate …

The neural crest is a dynamic progenitor cell population that arises at the border of neural
and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP at the neural plate …

Peripheral sympathetic nervous system tumors are the most common extracranial solid
tumors of childhood and include neuroblastoma, ganglioneuroblastoma, and …

Background Glial cell ensheathment of specific components of neuronal circuits is essential
for nervous system function. Although ensheathment of axonal segments of differentiated …

The neural crest shows an astonishing multipotency, generating multiple neural derivatives,
but also pigment cells, skeletogenic and other cell types. The question of how this process is …