Macrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to …

During development and throughout adult life, macrophages derived from hematopoietic
progenitors are seeded throughout the body, initially in the absence of inflammatory and …

It is well established that microglial form and function are inextricably linked. In recent years,
the traditional view that microglial form ranges between “ramified resting” and “activated …

The brain contains numerous mononuclear phagocytes called microglia. These cells
express the transmembrane tyrosine kinase receptor for the macrophage growth factor …

We have examined the distribution of microglia in the normal adult mouse brain using
immunocytochemical detection of the macrophage specific plasma membrane glycoprotein …

The most characteristic property of microglia is their swift activation in response to neuronal
stress and their capacity for site‐directed phagocytosis. The transformation of microglia into …

Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

Observations from different brain areas have established that the adult nervous system can
undergo significant experience-related structural changes throughout life. Less familiar is …

Purpose Microglia represent the primary resident immune cells in the CNS, and have been
implicated in the pathology of neurodegenerative diseases. Under basal or “resting” …

Microglia, the resident macrophages of the central nervous system, are characterised by a
highly specialized morphology and unusual antigenic phenotype. Microglia appear to be …