Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine

P Ahluwalia, K Ballur, T Leeman, A Vashisht, H Singh… - Cancers, 2024 - mdpi.com
Simple Summary Cancer affects millions of individuals every year, with colorectal cancer
being among the most common. There is an increased need to identify new biomarkers that …

Identification of metabolic pathways contributing to ER+ breast cancer disparities using a machine-learning pipeline

A Santaliz-Casiano, D Mehta, OC Danciu, H Patel… - Scientific reports, 2023 - nature.com
African American (AA) women in the United States have a 40% higher breast cancer
mortality rate than Non-Hispanic White (NHW) women. The survival disparity is particularly …

Pilot multi-omic analysis of human bile from benign and malignant biliary strictures: a machine-learning approach

JM Urman, JM Herranz, I Uriarte, M Rullán, D Oyón… - Cancers, 2020 - mdpi.com
Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the
development of extrahepatic obstructive cholestasis. However, biliary stenoses can also be …

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

JL Alexander, JM Posma, A Scott, L Poynter, SE Mason… - Microbiome, 2023 - Springer
Background and aims The gut microbiota is implicated in the pathogenesis of colorectal
cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define …

Regulation of Tumor Apoptosis of Poriae cutis-Derived Lanostane Triterpenes by AKT/PI3K and MAPK Signaling Pathways In Vitro

S Yue, X Feng, Y Cai, SA Ibrahim, Y Liu, W Huang - Nutrients, 2023 - mdpi.com
Poria cocos is traditionally used as both food and medicine. Triterpenoids in Poria cocos
have a wide range of pharmacological activities, such as diuretic, sedative and tonic …

Spatially resolved neuropeptide characterization from neuropathological formalin-fixed, paraffin-embedded tissue sections by a combination of imaging MALDI FT-ICR …

YL Cintron-Diaz, ME Gomez-Hernandez… - Journal of the …, 2022 - ACS Publications
To make the vast collections of well-documented human clinical samples archived in
biobanks accessible for mass spectrometry imaging (MSI), recent developments have …

miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1

S Chen, Y Wang, M Xu, L Zhang, Y Su, B Wang… - Molecular and cellular …, 2020 - Elsevier
MicroRNA (miRNA) exerts an important part in colon cancer cell proliferation and apoptosis.
Meanwhile, the dysregulation of some miRNAs is detected in colon cancer cells. However, it …

Sequential orbitrap secondary ion mass spectrometry and liquid extraction surface analysis-tandem mass spectrometry-based metabolomics for prediction of brain …

J Meurs, DJ Scurr, A Lourdusamy, LCD Storer… - Analytical …, 2021 - ACS Publications
We present here a novel surface mass spectrometry strategy to perform untargeted
metabolite profiling of formalin-fixed paraffin-embedded pediatric ependymoma archives …

Indication of high lipid content in epithelial-mesenchymal transitions of breast tissues

SN Sabtu, SFA Sani, LM Looi, SF Chiew… - Scientific reports, 2021 - nature.com
The epithelial-mesenchymal transition (EMT) is a crucial process in cancer progression and
metastasis. Study of metabolic changes during the EMT process is important in seeking to …

Clinical significance of screening differential metabolites in ovarian cancer tissue and ascites by LC/MS

M Liu, Y Liu, H Feng, Y Jing, S Zhao, S Yang… - Frontiers in …, 2021 - frontiersin.org
Tumor cells not only show a vigorous metabolic state, but also reflect the disease
progression and prognosis from their metabolites. To judge the progress and prognosis of …