Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

Protein misfolding into amyloid fibrils is linked to more than 40 as yet incurable cell‐and
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and type 2 …

Despite much effort, antibody therapies for Alzheimer's disease (AD) have shown limited
efficacy. Challenges to the rational design of effective antibodies include the difficulty of …

Aggregated tau protein is associated with over 20 neurological disorders, which include
Alzheimer's disease. Previous work has shown that tau's sequence segments VQIINK and …

Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by
which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope …

Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …

The elucidation of the cause of Alzheimer's disease remains one of the greatest questions in
neurodegenerative research. The lack of highly reliable low-cost sensors to study the …

Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …

Interactions among β-sheets occur widely in protein quaternary structure, protein–protein
interaction, and protein aggregation and are central in Alzheimer's and other amyloid …

The amyloid protein aggregation associated with diseases such as Alzheimer's, Parkinson's
and type II diabetes (among many others) features a bewildering variety of β-sheet-rich …