Langerhans cell histiocytosis (LCH) is a rare disease affecting people of any age, with
widely variable clinical manifestations and different outcomes. The precise chain of events …

Objective In IBD, interleukin-23 (IL-23) and its receptor (IL-23R) are implicated in disease
initiation and progression. Novel insight into which cells produce IL-23 at the site of …

Background Langerhans cell histiocytosis (LCH) is a disease that arises from myeloid cells
that phenotypically resemble Langerhans cells (LC), which is typically driven by the BRAF …

Stromal cells support epithelial cell and immune cell homeostasis and play an important role
in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response …

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm caused by
aberrant activation of the mitogen-activated protein kinase (MAPK) pathway. Circulating …

The majority of T cells present in the bone marrow (BM) represent an activated/memory
phenotype and most of these, if not all, are circulating T cells. Their lodging in the BM keeps …

Background The relationship between various external agents such as pollen, food, and
infectious agents and human sensitivity exists and is variable depending upon individual's …

Langerhans cell histiocytosis (LCH) lesions are defined by the presence of CD1a+/CD207+
myeloid cells, but many other immune cells are present including unconventional T cells …

Langerhans cell histiocytosis (LCH) is a potentially life-threatening inflammatory myeloid
neoplasia linked to pediatric neurodegeneration, whereby transformed LCH cells form …

Background Increased risk of infection in neonates, including foals, is associated with the
naivety of the immune system and the immaturity of the endocrine system. Foal dendritic …