Notch is a key evolutionary conserved pathway, which has fascinated and engaged the work
of investigators in an uncountable number of biological fields, from development of …

Hematopoietic stem cells (HSCs) surface during embryogenesis leading to the genesis of
the hematopoietic system, which is vital for immune function, homeostasis balance, and …

Human hematopoietic stem cells (HSCs), which arise from aorta-gonad-mesonephros
(AGM), are widely used to treat blood diseases and cancers. However, a technique for their …

Background Human induced pluripotent stem cells (hiPSCs) offer a renewable source of
cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and …

Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR) T cells holds impressive
clinical outcomes especially in patients who are refractory to other kinds of therapy …

Adoptive therapies with genetically modified somatic T cells rendered HIV resistance have
shown promise for AIDS therapy. A renewable source of HIV-resistant human T cells from …

Numerous human disorders of the blood system would directly or indirectly benefit from
therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem …

Induced pluripotent stem cell (iPSC)-derived T (iT) cells represent a groundbreaking frontier
in adoptive cell therapies with engineered T cells, poised to overcome pivotal limitations …

Fate decisions in the embryo are controlled by a plethora of microenvironmental interactions
in a three‐dimensional niche. To investigate whether aspects of this microenvironmental …

The generation of immune cells from human pluripotent stem cells (embryonic stem cells
and induced pluripotent stem cells) has been of keen interest to regenerative medicine …