The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …

The synthesis of secondary and tertiary amines through the reductive amination of carbonyl
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …

The synthesis of primary amines through reductive/hydrogen-borrowing amination has
garnered significant attention due to their wide application in the chemical industry. The key …

Direct asymmetric reductive amination is one of the most efficient methods for the
construction of chiral amines, in which the scope of the applicable amine coupling partners …

Regio-and stereoselective reductive amination of diketones offers an attractive method to
access chiral β-amino ketones with multiple stereocenters which are unique scaffolds and …

Carbon monoxide is an indispensable C1 building block that has been recognized as a
potent feedstock for synthesizing carbonyl-containing molecules. Carbonylative reactions …

Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered
media are described, representative of the enhanced levels of conversion made possible by …

The chiral building block 5-amino-2-hydroxymethyltetrahydropyran 1a has been previously
synthesized through a cumbersome 9-step synthesis from tri-O-acetyl-D-glucal, which …

The enantioselective synthesis of chiral fluorinated amines is of great importance but highly
challenging in synthetic chemistry and the pharmaceutical industry. Herein, we established …

The efficient asymmetric catalytic synthesis of amines containing more than one stereogenic
center is a current challenge. Here, we present a biocatalytic cascade that combines ene …