The composition of the oral microbiome differs from one intraoral site to another, reflecting in
part the host response and immune capacity at each site. By focusing on two major oral …

Recent metagenomic and mechanistic studies are consistent with a new model of
periodontal pathogenesis. This model proposes that periodontal disease is initiated by a …

Toll-like receptors play a critical role in innate immunity by detecting invading pathogens.
The ability of TLRs to engage different intracellular signaling molecules and cross-talk with …

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

Evidence from epidemiologic studies suggests that periodontal infections are independently
associated with subclinical and clinical atherosclerotic vascular disease. Although the …

In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved
ingenious ways to evade host immune responses. In this Review, we focus on'crosstalk …

Even though animal models have limitations, they are often superior to in vitro or clinical
studies in addressing mechanistic questions and serve as an essential link between …

Porphyromonas gingivalis is a Gram-negative anaerobic rod that has been proposed as an
orchestrator of complement-dependent dysbiotic inflammation. This notion was suggested …

The Toll-like receptors (TLRs) and complement are key innate defense systems that are
triggered rapidly upon infection. Although both systems have been investigated primarily as …

Viruses successfully infect host cells by initially binding to the surfaces of the cells, followed
by an intricate entry process. As multifunctional heterodimeric cell-surface receptor …