[HTML][HTML] ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers
Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs characterized
by a covalently closed-loop structure generated through a special type of alternative splicing …
by a covalently closed-loop structure generated through a special type of alternative splicing …
Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages
C Drummer IV, F Saaoud, NC Jhala, R Cueto… - Frontiers in …, 2023 - frontiersin.org
Introduction Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the
population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges …
population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges …
[HTML][HTML] IL-35 promotes CD4+ Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms
Tregs play vital roles in suppressing atherogenesis. Pathological conditions reshape Tregs
and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function …
and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function …
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
Endothelial immunity trained by coronavirus infections, DAMP stimulations and regulated by anti-oxidant NRF2 may contribute to inflammations, myelopoiesis, COVID …
To characterize transcriptomic changes in endothelial cells (ECs) infected by coronaviruses,
and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) …
and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) …
[HTML][HTML] Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but …
It has been shown that anti-inflammatory cytokines interleukin-35 (IL-35) and IL-10 could
inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what …
inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what …
IL-35 (interleukin-35) suppresses endothelial cell activation by inhibiting mitochondrial reactive oxygen species-mediated site-specific acetylation of H3K14 (histone 3 …
Objective—IL-35 (interleukin-35) is an anti-inflammatory cytokine, which inhibits immune
responses by inducing regulatory T cells and regulatory B cells and suppressing effector T …
responses by inducing regulatory T cells and regulatory B cells and suppressing effector T …
Caspase-4/11 promotes hyperlipidemia and chronic kidney disease–accelerated vascular inflammation by enhancing trained immunity
To determine whether hyperlipidemia and chronic kidney disease (CKD) have a synergy in
accelerating vascular inflammation via trained immunity (TI), we performed aortic …
accelerating vascular inflammation via trained immunity (TI), we performed aortic …