Keeping up with a Quickly Diversifying Pharmaceutical Landscape

A Goyon - ACS Measurement Science Au, 2024 - ACS Publications
Small molecules and antibodies have dominated the pharmaceutical landscape for
decades. However, limitations associated with therapeutic targets deemed" undruggable" …

Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses

J Camperi, B Roper, E Freund, R Leylek… - Analytical …, 2024 - ACS Publications
Advances in mRNA technology have enabled mRNA-based therapies to enter a new era of
medicine. Such therapies benefit from a single, standardized in vitro transcription (IVT) …

[HTML][HTML] Evaluation of ion pairing reversed-phase liquid chromatography for the separation of large RNA molecules

J Maurer, C Malburet, M François-Heude… - … of Chromatography A, 2025 - Elsevier
The rapid development of mRNA-based therapeutics, especially post-COVID-19, has
necessitated the precise characterization of mRNA quality attributes, including sequence …