The neonatal crystallizable fragment receptor (FcRn) was initially discovered as the receptor
that allowed passive immunity in newborns by transporting maternal IgG through the …

Purpose: Exposure to HLA alloantigens through pregnancy, blood products and previous
transplantations induce powerful immunologic responses that create an immunologic barrier …

Genetic modification of porcine donors, combined with optimized immunosuppression, has
been shown to improve outcomes of experimental xenotransplant. However, little is known …

Background Highly sensitized patients face many barriers to kidney transplantation,
including higher rates of antibody‐mediated rejection after HLA‐incompatible transplant …

Sensitized patients, those who had prior exposure to foreign human leukocyte antigens, are
transplanted at lower rates due to challenges in finding suitable organs. Desensitization …

Advances in desensitization for human leukocyte antigen inco... : Current Opinion in Organ
Transplantation Advances in desensitization for human leukocyte antigen incompatible kidney …

Introduction One-third of HLA-incompatible kidney transplant recipients experience antibody
mediated rejection (AMR) with limited treatment options. This study describes a novel …

Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and
plasma cells, we have developed strategies in a non-human primate model to modulate the …

Among sensitized patients awaiting a transplant, females are disproportionately
represented, partly because of pregnancy-induced sensitization. Using female NHPs …

The biological products are mainly composed of biologics, biosimilars, and interchangeable
products (biosimilar themselves) and are categorized as a class of bioactive …