The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Context Intermittent fasting (IF) is an effective strategy to improve cardiometabolic health.
Objective The objective of this work is to examine the effects of IF on cardiometabolic risk …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control
cytokine-induced peroxide levels which mediate signal transduction in mammalian cells …

Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …

A hallmark of tuberculosis is the ability of the causative agent, Mycobacterium tuberculosis,
to persist for decades despite a vigorous host immune response. Previously, we identified a …

Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

Acting as a signal, hydrogen peroxide circumvents antioxidant defense by overoxidizing
peroxiredoxins (Prxs), the enzymes that metabolize peroxides. We show that sestrins, a …

Infections with Mycobacterium tuberculosis remain a major cause of disease and death in
humans. Among the factors that contribute to M. tuberculosis's success as a pathogen is its …