Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

Cellular studies have long been performed on the bench top, within Petri dishes and flasks
that expose cells to surroundings that differ greatly from their native environment. The …

The Hippo tumour suppressor pathway is a conserved signalling pathway that controls
organ size. The core of the Hpo pathway is a kinase cascade, which in Drosophila involves …

Background A number of adhesion-mediated signaling pathways and cell-cycle events have
been identified that regulate cell proliferation, yet studies to date have been unable to …

Recent methods have revealed that cells on planar substrates exert both shear (in-plane)
and normal (out-of-plane) tractions against the extracellular matrix (ECM). However, the …

To exploit the full potential of human pluripotent stem cells for regenerative medicine,
developmental biology and drug discovery, defined culture conditions are needed. Media of …

Arterial stiffening is a risk factor for cardiovascular disease, but how arteries stay supple is
unknown. Here, we show that apolipoprotein E (apoE) and apoE-containing high-density …

In damaged kidneys, increased extracellular matrix (ECM) and tissue stiffness stimulate
kidney fibrosis through incompletely characterized molecular mechanisms. The …

Reaping the promise of human embryonic stem (hES) cells hinges on effective defined
culture conditions. Efforts to identify chemically defined environments for hES cell …

Driven by specific extracellular matrix cues, endothelial cells can spontaneously assemble
into networks. Cell network assembly is, in part, dictated by both substrate stiffness and …