The general stress response (GSR) is a widespread strategy developed by bacteria to adapt
and respond to their changing environments. The GSR is induced by one or multiple …

The bacterium Escherichia coli is a major host for recombinant protein production of non-
glycosylated products. Depending on the expression strategy, the recombinant protein can …

Metabolic engineering and synthetic biology have enabled the use of microbial production
platforms for the renewable production of many high-value natural products. Titers and …

Genome-scale engineering is indispensable in understanding and engineering
microorganisms, but the current tools are mainly limited to bacterial systems. Here we report …

Adenosine triphosphate (ATP) is an abundant and essential metabolite that cells consume
and regenerate in large amounts to support growth. Although numerous studies have …

Freshwater ecosystems are critical but fragile environments directly affecting society and its
welfare. However, our understanding of genuinely freshwater microbial communities …

Genistin is one of the bioactive isoflavone glucosides found in legumes, which have great
nutraceutical and pharmaceutical significance. The market available isoflavones are …

Overflow metabolism refers to the production of seemingly wasteful by-products by cells
during growth on glucose even when oxygen is abundant. Two theories have been …

NADP (H) is a central metabolic hub providing reducing equivalents to multiple biosynthetic,
regulatory and antioxidative pathways in all living organisms. While biosensors are …

Ethylene glycol (EG) derived from plastic waste or CO2 can serve as a substrate for
microbial production of value-added chemicals. Assimilation of EG proceeds though the …