Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery

B Kim, JH Park, MJ Sailor - Advanced materials, 2019 - Wiley Online Library
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

Clinical translation of nanomedicine

Y Min, JM Caster, MJ Eblan, AZ Wang - Chemical reviews, 2015 - ACS Publications
Clinical Translation of Nanomedicine | Chemical Reviews ACS ACS Publications C&EN CAS
Find my institution Log In Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most …

Recent advances in metal nanoparticles in cancer therapy

A Sharma, AK Goyal, G Rath - Journal of drug targeting, 2018 - Taylor & Francis
Metal nanoparticles (NPs) may have the potential to overcome problems related to
conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in …

Nano-based delivery of RNAi in cancer therapy

Y Xin, M Huang, WW Guo, Q Huang, L Zhang, G Jiang - Molecular cancer, 2017 - Springer
Background RNA interference (RNAi), a newly developed method in which RNA molecules
inhibit gene expression, has recently received considerable research attention. In the …

[HTML][HTML] Gene therapy in cancer treatment: why go nano?

C Roma-Rodrigues, L Rivas-García, PV Baptista… - Pharmaceutics, 2020 - mdpi.com
The proposal of gene therapy to tackle cancer development has been instrumental for the
development of novel approaches and strategies to fight this disease, but the efficacy of the …

Multifunctional gold nanoparticles for diagnosis and therapy of disease

AJ Mieszawska, WJM Mulder, ZA Fayad… - Molecular …, 2013 - ACS Publications
Gold nanoparticles (AuNPs) have a number of physical properties that make them appealing
for medical applications. For example, the attenuation of X-rays by gold nanoparticles has …

Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine

J Conde, JT Dias, V Grazú, M Moros… - Frontiers in …, 2014 - frontiersin.org
In the last 30 years we have assisted to a massive advance of nanomaterials in material
science. Nanomaterials and structures, in addition to their small size, have properties that …

Designing hydrogels for on-demand therapy

N Oliva, J Conde, K Wang, N Artzi - Accounts of chemical …, 2017 - ACS Publications
Conspectus Systemic administration of therapeutic agents has been the preferred approach
to treat most pathological conditions, in particular for cancer therapy. This treatment modality …