RNA-polymer hybrids via direct and site-selective acylation with the ATRP initiator and photoinduced polymerization
Combining synthetic polymers with RNA paves the way for creating RNA-based materials
with non-canonical functions. We have developed an acylation reagent that allows for direct …
with non-canonical functions. We have developed an acylation reagent that allows for direct …
Bioorthogonal masked acylating agents for proximity-dependent RNA labelling
RNA localization is highly regulated, with subcellular organization driving context-
dependent cell physiology. Although proximity-based labelling technologies that use highly …
dependent cell physiology. Although proximity-based labelling technologies that use highly …
2′-OH as a universal handle for studying intracellular RNAs
RNA plays pivotal roles in most cellular processes, serving as both the traditional carrier of
genetic information and as a key regulator of cellular functions. The advent of chemical …
genetic information and as a key regulator of cellular functions. The advent of chemical …
Inserting “OFF-to-ON” BODIPY tags into cytokines: a fluorogenic interleukin IL-33 for real-time imaging of immune cells
AE Reese, F de Moliner, L Mendive-Tapia… - ACS Central …, 2023 - ACS Publications
The essential functions that cytokine/immune cell interactions play in tissue homeostasis
and during disease have prompted the molecular design of targeted fluorophores to monitor …
and during disease have prompted the molecular design of targeted fluorophores to monitor …
Chemical Diversity of Reagents that Modify RNA 2'-OH in Water: a Review
Electrophilic water-soluble compounds have proven versatile in reacting selectively with 2′-
OH groups in RNA, enabling structure mapping, probing, caging, labeling, crosslinking, and …
OH groups in RNA, enabling structure mapping, probing, caging, labeling, crosslinking, and …
Stereoselective RNA reaction with chiral 2′-OH acylating agents
The reactivity of RNA 2′-OH groups with acylating agents has recently been investigated
for high-yield conjugation of RNA strands. To date, only achiral molecules have been …
for high-yield conjugation of RNA strands. To date, only achiral molecules have been …
Second-Generation Chiral Amino Acid Derivatives Afford High Stereoselectivity and Stability in Aqueous RNA Acylation
Activated acyl species have proven versatile in the esterification of 2′–OH groups in RNA,
enabling structure mapping, caging, profiling, and labeling of the biopolymer. Nearly all …
enabling structure mapping, caging, profiling, and labeling of the biopolymer. Nearly all …
Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation
Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation
- Chemical Communications (RSC Publishing) DOI:10.1039/D3CC05123D Royal Society of …
- Chemical Communications (RSC Publishing) DOI:10.1039/D3CC05123D Royal Society of …
Regulating CRISPR/Cas9 Using Streptavidin‐Biotin Interactions†
W Shen, W Xiong, Q Qi, X Liu, Z Xie… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Currently, CRISPR/Cas9 technology has found widespread
applications across various domains. However, the utility of CRISPR/Cas9 is encumbered …
applications across various domains. However, the utility of CRISPR/Cas9 is encumbered …
RNA infrastructure profiling illuminates transcriptome structure in crowded spaces
RNAs fold into compact structures and undergo protein interactions in cells. These occluded
environments can block reagents that probe the underlying RNAs. Probes that can analyze …
environments can block reagents that probe the underlying RNAs. Probes that can analyze …