Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

An essential component of allogeneic and autologous hematopoietic cell transplantation
(HCT) is the conditioning regimen administered before the hematopoietic cell infusion. Early …

Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

The year 2009 marked the fiftieth anniversary of the first successful allogeneic
haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the …

Graft-vs. host disease (GVHD), both acute and chronic are among the chief non-relapse
complications of allogeneic transplantation which still cause substantial morbidity and …

Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow
transplantation whereby transplanted naive and marrow-derived T cells damage recipient …

The last 6 decades have seen major advances in the understanding of immunologic
diseases, driven by preclinical animal models. Indeed, bone marrow transplantation (BMT) …

Microbial diversity is associated with improved outcomes in recipients of allogeneic
hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this …

For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

Unconventional T cells are a diverse and underappreciated group of relatively rare
lymphocytes that are distinct from conventional CD4+ and CD8+ T cells, and that mainly …