Terpenes are the largest class of small‐molecule natural products on earth, and the most
abundant by mass. Here, we summarize recent developments in elucidating the structure …

The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

The phosphate moiety (PO4-2) is the common structural motif of a wide range of natural
phosphorus-based biologically active compounds, which play important roles as metabolic …

Nitrogen-containing bisphosphonates (nBPs) are bone-specific agents that inhibit farnesyl
diphosphate synthase. nBPs' strong affinity for bone, and not for other tissues, makes them …

Sterols are constituents of the cellular membranes that are essential for their normal
structure and function. In mammalian cells, cholesterol is the main sterol found in the various …

Chemistry and Application of H-Phosphonates is an excellent source for those planning the
synthesis of new phosphorus-containing compounds and in particular derivatives containing …

Human Vγ2Vδ2 T cells monitor isoprenoid metabolism by recognizing (E)-4-hydroxy-3-
methyl-but-2-enyl pyrophosphate (HMBPP), an intermediate in the 2-C-methyl-d-erythritol-4 …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …