New routes and opportunities for modular construction of particulate vaccines: stick, click, and glue
Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-
chimeric VLP-based vaccines are highly successful licensed products (eg, hepatitis B …
chimeric VLP-based vaccines are highly successful licensed products (eg, hepatitis B …
Site-specific dual encoding and labeling of proteins via genetic code expansion
RM Bednar, PA Karplus, RA Mehl - Cell chemical biology, 2023 - cell.com
The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …
avenues for manipulating, engineering, and studying living systems. As a chemical biology …
A semi-synthetic organism that stores and retrieves increased genetic information
Y Zhang, JL Ptacin, EC Fischer, HR Aerni, CE Caffaro… - Nature, 2017 - nature.com
Since at least the last common ancestor of all life on Earth, genetic information has been
stored in a four-letter alphabet that is propagated and retrieved by the formation of two base …
stored in a four-letter alphabet that is propagated and retrieved by the formation of two base …
Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization
Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …
Programmable polyproteams built using twin peptide superglues
G Veggiani, T Nakamura, MD Brenner… - Proceedings of the …, 2016 - National Acad Sciences
Programmed connection of amino acids or nucleotides into chains introduced a revolution in
control of biological function. Reacting proteins together is more complex because of the …
control of biological function. Reacting proteins together is more complex because of the …
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
A Ordureau, JM Heo, DM Duda… - Proceedings of the …, 2015 - National Acad Sciences
The PTEN-induced putative kinase protein 1 (PINK1) and ubiquitin (UB) ligase PARKIN
direct damaged mitochondria for mitophagy. PINK1 promotes PARKIN recruitment to the …
direct damaged mitochondria for mitophagy. PINK1 promotes PARKIN recruitment to the …
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
Expansion of the genetic code with nonstandard amino acids (nsAAs) has enabled
biosynthesis of proteins with diverse new chemistries. However, this technology has been …
biosynthesis of proteins with diverse new chemistries. However, this technology has been …
Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog
DT Rogerson, A Sachdeva, K Wang, T Haq… - Nature chemical …, 2015 - nature.com
Serine phosphorylation is a key post-translational modification that regulates diverse
biological processes. Powerful analytical methods have identified thousands of …
biological processes. Powerful analytical methods have identified thousands of …
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase
and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on the …
and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on the …
New codons for efficient production of unnatural proteins in a semisynthetic organism
EC Fischer, K Hashimoto, Y Zhang… - Nature Chemical …, 2020 - nature.com
Natural organisms use a four-letter genetic alphabet that makes available 64 triplet codons,
of which 61 are sense codons used to encode proteins with the 20 canonical amino acids …
of which 61 are sense codons used to encode proteins with the 20 canonical amino acids …