Understanding the role of interleukin-6 (IL-6) in the joint and beyond: a comprehensive review of IL-6 inhibition for the management of rheumatoid arthritis

EG Favalli - Rheumatology and therapy, 2020 - Springer
Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disorder involving
inflammation and progressive destruction of the joints, affecting up to 1% of the population …

[PDF][PDF] Pain mechanisms in rheumatoid arthritis

DF McWilliams, DA Walsh - Clin exp rheumatol, 2017 - clinexprheumatol.org
Understanding of the causes and underlying mechanisms of pain in people with RA is
rapidly changing. With the advent of more effective disease modifying drugs, joint …

International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials

AM Orbai, M De Wit, P Mease, JA Shea… - Annals of the …, 2017 - ard.bmj.com
Objective To identify a core set of domains (outcomes) to be measured in psoriatic arthritis
(PsA) clinical trials that represent both patients' and physicians' priorities. Methods We …

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and …

DB Kell, E Pretorius - Integrative Biology, 2015 - academic.oup.com
We have recently highlighted (and added to) the considerable evidence that blood can
contain dormant bacteria. By definition, such bacteria may be resuscitated (and thus …

[图书][B] S2e-Leitlinie Therapie der rheumatoiden Arthritis mit krankheitsmodifizierenden Medikamenten

C Fiehn, J Holle, C Iking-Konert, J Leipe, C Weseloh… - 2018 - register.awmf.org
Hintergrund: Medikamentöse Therapiestrategien zur Behandlung der rheumatoiden Arthritis
sind entscheidend für den Langzeitverlauf. Sie dienen dem Ziel, durch frühe und …

Call for action: how to improve use of patient-reported outcomes to guide clinical decision making in rheumatoid arthritis

B Fautrel, R Alten, B Kirkham, I de La Torre… - Rheumatology …, 2018 - Springer
Current guidelines for the management of rheumatoid arthritis (RA) recommend early
treatment and a treat-to-target goal of remission or low disease activity. Over the past …

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

EM Bouta, RD Bell, H Rahimi, L Xing… - Nature Reviews …, 2018 - nature.com
Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

Patient reported outcomes in rheumatoid arthritis clinical trials

AM Orbai, CO Bingham - Current rheumatology reports, 2015 - Springer
Patient reported outcomes (PRO) are at the core of assessing RA treatment response with
patient assessments of global health or disease activity, pain, and physical function included …

Nonpharmacological treatment in established rheumatoid arthritis

AA Küçükdeveci - Best Practice & Research Clinical Rheumatology, 2019 - Elsevier
The goals in the management of established rheumatoid arthritis (RA) are to control pain
and disease activity, prevent further joint damage, and enhance functioning and quality of …

S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs

C Fiehn, J Holle, C Iking-Konert, J Leipe… - Zeitschrift für …, 2018 - Springer
Zusammenfassung Hintergrund Medikamentöse Therapiestrategien zur Behandlung der
rheumatoiden Arthritis sind entscheidend für den Langzeitverlauf. Sie dienen dem Ziel …