Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …

Substance use disorders (SUDs) are highly prevalent. SUDs involve vicious cycles of binges
followed by occasional periods of abstinence with recurrent relapses despite treatment and …

Familial inheritance of drug abuse is composed of both genetic and environmental factors.
Additionally, epigenetic transgenerational inheritance may provide a means by which …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function. While genetic factors are important in the etiology of …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Recent evidence has demonstrated that the gut microbiome has marked effects on neuronal
function and behavior. Disturbances to microbial populations within the gut have been …

Dysregulation of histone modifying enzymes has been associated with numerous psychiatric
disorders. Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the …

Background Opiate abuse and overdose reached epidemic levels in the United States.
However, despite significant advances in animal and in vitro models, little knowledge has …

Abstract Opioid Use Disorder (OUD) is a chronic relapsing clinical condition with
tremendous morbidity and mortality that frequently persists, despite treatment, due to an …