Membrane proteins mediate flow of molecules, signals, and energy between cells and
intracellular compartments. Understanding membrane protein function requires a detailed …

For a long time, solid-state nuclear magnetic resonance (ssNMR) has been employed to
study complex biomolecular systems at the detailed chemical, structural, or dynamic level …

The epidermal growth factor receptor (EGFR) represents one of the most common target
proteins in anti-cancer therapy. To directly examine the structural and dynamical properties …

Studying biomolecules at atomic resolution in their native environment is the ultimate aim of
structural biology. We investigated the bacterial type IV secretion system core complex …

Supramolecular chemistry provides structural and conformational information about
complexes formed from multiple molecules. While the molecule is held together by strong …

Membrane proteins remain challenging targets for structural biology, despite much effort, as
their native environment is heterogeneous and complex. Most methods rely on detergents to …

Cholesterol directs the pathway of ligand-induced G protein-coupled receptor (GPCR) signal
transduction. The GPCR C–C motif chemokine receptor 3 (CCR3) is the principal …

Increasing evidence suggests that most proteins occur and function in complexes rather
than as isolated entities when embedded in cellular membranes. Nuclear magnetic …

The prerequisite to structural or functional studies of proteins by NMR is generally the
assignment of resonances. Since the first assignment of proteins by solid-state MAS NMR …

We show that selective labeling of proteins with protonated amino acids embedded in a
perdeuterated matrix, dubbed 'proton clouds', provides general access to long-range …